Wellness
June 18, 2026·5 min read
Clients ask about NAD+ IV therapy more than almost anything else on the wellness menu right now. They've read about it, seen it on podcasts, heard it described in ways that sound almost too good. So here's what I actually tell people when they sit down with me — including the parts that are still uncertain.
NAD+ stands for nicotinamide adenine dinucleotide — a coenzyme that is, in a meaningful sense, foundational to how your cells produce energy. It participates in hundreds of metabolic reactions, including the ones that allow mitochondria to do their job. Without adequate NAD+, cellular energy metabolism slows.
What the research shows is that NAD+ levels decline with age. A frequently cited body of work in aging biology — including studies published through the National Institute on Aging — has documented this decline in human tissue and in animal models, and researchers are actively investigating whether replenishing NAD+ has measurable downstream effects on metabolic function. The science is real and it is serious. It is also still maturing. NIH-funded research on NAD+ precursor supplementation and aging biology is ongoing, and the clinical picture is not yet fully drawn.
That distinction — between promising basic science and established clinical outcomes — is the honest starting point for any conversation about nicotinamide adenine dinucleotide IV therapy.
I want to be direct about something before we go further.
NAD+ IV infusions are administered off-label at Enhance Aesthetics & Wellness. NAD+ is not FDA-approved for any therapeutic indication. The injectable formulation is a compounded preparation — meaning it is prepared by a licensed compounding pharmacy under a 503A patient-specific prescription following an individualized medical evaluation with me. The FDA has also placed injectable NAD+ on its 503A nominated-for-evaluation list, which is exactly the kind of regulatory context you deserve to know going in.
Off-label medication disclosure: NAD+ infusions are administered off-label. NAD+ is not FDA-approved for any indication. Marina Roloff, DNP, FNP-C, will discuss the off-label nature of this therapy and individualized risk/benefit at your consultation.
Compounded medication disclosure: Injectable NAD+ is a compounded preparation. The FDA has placed injectable NAD+ on its 503A nominated-for-evaluation list.
None of this means the therapy isn't worth discussing. Off-label use is a normal part of clinical medicine — providers use many interventions outside their original labeled indication when there is a reasonable evidence basis and when clients understand what they're consenting to. What it does mean is that you should be sitting across from someone who is willing to say all of this out loud before you start, not after.
The research on NAD+ is concentrated in a few areas. Studies indexed on PubMed have investigated NAD+ metabolism, its role in mitochondrial function, and the potential effects of NAD+ precursor supplementation in aging populations. Animal-model data is robust. Human trials using oral NAD+ precursors (primarily NMN and NR) have shown that supplementation can raise circulating NAD+ levels — and some trials have suggested effects on metabolic markers. The IV route delivers NAD+ more directly into the bloodstream, bypassing the digestive variability of oral forms, though head-to-head comparisons between routes are limited in the published literature.
What is less established: whether raising NAD+ levels through IV infusion produces clinically meaningful, durable changes in how people feel or function — and at what dose, frequency, or in which populations. That gap between mechanism and outcome is where I want clients to land before they commit to anything.
I am not going to describe this therapy as something that sharpens mental clarity, supports total-body vitality, or reverses any aging process. Those framings go beyond what the current evidence supports for off-label compounded IV NAD+, and I won't use them here.
We are part of the broader health and wellness services at Enhance because it fits within a root-cause, optimization-oriented approach to care — not because it comes with guaranteed outcomes.
For clients who are already working on the fundamentals — sleep, nutrition, stress management, hormone optimization where indicated — and who want to explore what the NAD+ research might mean for them personally, the conversation is worth having. For clients who are looking for a single intervention to feel dramatically better quickly, I'm going to say so plainly: that's not the right frame for this therapy, and probably not for most things I offer.
The infusion itself takes time — longer than a standard IV hydration session. NAD+ infusions are typically administered slowly because faster infusion rates can cause discomfort. That pacing is part of the clinical protocol, not a limitation we apologize for. If you've read about that elsewhere and wondered, now you know.
Yuma summers are a relevant backdrop here. Extended heat exposure, high physical demand, and the chronic dehydration patterns we see in desert climates can put real stress on cellular systems. Whether that stress affects NAD+ metabolism in ways that make IV replenishment more relevant for clients in this climate is an interesting question — and one we can explore together in the context of your specific history, not in a general marketing claim. If you've already read about IV hydration in the Yuma summer, you have some context for the physiological demands this environment places on the body.
If this resonates, here is what I want you to expect from a consultation at Enhance: a real conversation about what the science says and doesn't say, about your health history and what might make you a reasonable candidate, and about the off-label nature of this therapy in a way that leaves you genuinely informed — not sold.
I don't rush that conversation. The first visit is a conversation, and there is no pressure to commit to anything beyond that.
Statements about NAD+ have not been evaluated by the FDA. NAD+ infusions are not intended to diagnose, treat, cure, or prevent any disease.
If you'd like to talk through whether NAD+ IV therapy makes sense for you, schedule a consultation at Enhance Aesthetics & Wellness or call 928.370.4480.
Information on this page is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Individual results vary; outcomes shown or described are not guaranteed. Compounded medications referenced (including NAD+) are prepared by licensed compounding pharmacies under 503A patient-specific prescriptions and are not FDA-approved finished pharmaceutical products. Consult an Enhance clinician for guidance specific to your situation. Images may contain models. © 2026 Enhance Aesthetics & Wellness.
Medically reviewed by Marina Roloff, DNP, FNP-C — 2026-06-18
Schedule a Consultation
Marina Roloff, DNP, FNP-C — Enhance Aesthetics & Wellness, Yuma, AZ
CONTACT US